How Xenazine® (tetrabenazine) Works
Individual results may vary. Xenazine may not be effective in reducing choreic movements in all HD patients. Please review the Important Safety Information, including Boxed Warning about the increased risk of depression and suicidality, below.
Chorea Symptoms in Huntington's Disease
Dr. Sung discusses how chorea can affect Huntington's disease patients.
Craig and Sara's Huntington's Disease Story
Watch Craig and Sara discuss their experiences with chorea associated with Huntington's disease and how it can affect the entire family.
Matt’s HD Chorea
See how Matt and his caregiver and wife, Karen, worked to find treatment options, including Xenazine, to help manage his HD chorea.
Medication Assistance Program: REACH
Learn about Lundbeck’s medication assistance program, REACH, which offers financial assistance for Xenazine patients who qualify.
How Xenazine exactly reduces HD chorea is not known. It is thought that Xenazine reduces the amount of certain chemicals in the brain that help control body movement.
It is important to remember, Xenazine may reduce the involuntary movements of HD chorea but cannot cure the cause of these movements.
In a clinical trial with HD patients, chorea symptoms were significantly reduced at the end of the 12-week trial in more than two-thirds of patients taking Xenazine.2 The remaining patients (less than one third) either showed no change in their HD chorea symptoms or their symptoms worsened.3 The most commonly reported side effects in studies with Xenazine were sleepiness, trouble sleeping, depression, tiredness, anxiety, restlessness, agitation and nausea. Some side effects — such as depression, tiredness, trouble sleeping, sleepiness, parkinsonism, agitation and restlessness (akathisia) — may be dose-dependent. If the side effects don’t stop or lessen, your doctor should consider lowering the dose or stopping your Xenazine.